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RESEARCH
Identification of novel cancer metabolites to promote cancer
Cancer cells accumulate physiologically active cancer metabolites (known as oncotabolites) according to the extreme tumor microenvironments and contribute to aggressiveness of canccer such as cancer proliferation, invasion and metastasis. We aimed to identify unknown oncometabolites and examine their roles in cancer cells.
Understanding cancer metabolism in tumor microenvironments
Cancer cells acquire malignancy in extreme tumor microenvironments such as hypoxia, nutrient deprivation and acidic pH. Our goal is to elucidate multi-layer cancer metabolic adaptations against carbohydrates, lipids and amino acids that have been studied by independent paradigms.
Development of cancer therapies through comprehensive "Nutriomics"approach
Upon integration of genome, epigenome, transcriptome, proteome, and metabolome data through the comprehensive “Nutri-Omics” approach, we try to clarify the transcriptional-metabolic system in cancer cells accompanying tumor microenvironments, leading to the development of novel anti-cancer treatments.
MEMBERS
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We seek for talented students, technical staff members.
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FACILITY
A NEW STUDIO
A new open laboratory was refurbished on the 3rd floor of Building 4 of the Center for Advanced Science and Technology, University of Tokyo.
We provide a relaxed space for study.