Research Center for Advanced Science and Technology

Osawa Lab. Osawa Lab.

Make the future from TOKYO

Cancer research is entering a new era
We aimed to create novel cancer treatments
through "Nutriomics” approach,
the integration of nutrition and omics data



We aimed to create novel cancer treatments through "Nutriomics” approach

Cancer is one of the biggest issues of medicine and biology in the 21st century, and integration medicine, biology, engineering, and chemistry is essential for conquering cancer. Recent years, it has become clear that the extreme microenvironment surrounding cancer cells (Tumor microenvironment) promotes cancer progression. Our laboratory aims to develop novel cancer treatments from the comprehensive Nutri-Omics approach by integration of multi-layer omics of cancer cell including genome, epigenome, transcriptome, proteome, metabolome in terms of tumor microenvironments.

Division of Integrative Nutiriomics and Oncology,
Research Center for Advanced Science and Technology, The University of Tokyo

Tsuyoshi Osawa


Identification of novel cancer metabolites to promote cancer

Cancer cells accumulate physiologically active cancer metabolites (known as oncotabolites) according to the extreme tumor microenvironments and contribute to aggressiveness of canccer such as cancer proliferation, invasion and metastasis. We aimed to identify unknown oncometabolites and examine their roles in cancer cells.

Understanding cancer metabolism in tumor microenvironments

Cancer cells acquire malignancy in extreme tumor microenvironments such as hypoxia, nutrient deprivation and acidic pH. Our goal is to elucidate multi-layer cancer metabolic adaptations against carbohydrates, lipids and amino acids that have been studied by independent paradigms.

Development of cancer therapies through comprehensive "Nutriomics"approach

Upon integration of genome, epigenome, transcriptome, proteome, and metabolome data through the comprehensive “Nutri-Omics” approach, we try to clarify the transcriptional-metabolic system in cancer cells accompanying tumor microenvironments, leading to the development of novel anti-cancer treatments.


  • Associate Professor
    Tsuyoshi Osawa
  • Assistant Professor
    Sho Aki
  • Research Fellow (MD. PhD)
    Rika Tsuchida
  • Research Fellow (MD. PhD)
    Muyassar Anwar
  • Research Technitian
    Myuki Nishida
  • Research Technitian
    Maki Sugaya
  • Designer
    Ritsuko Ando
  • Secretary
    Aiko Hata
  • PhD Student
    Keisuke Maeda
  • PhD Student
    Ryuchi Nakahara
  • Master Student
    Sumire Nakagawa
  • Bachelor Student
    Takuma Ayano
  • Bachelor Student
    Arii Hirata
  • Bachelor Student
    Hana Obata
  • OG - Keio University, Faculty of Pharmacy
    Miki Kato
  • OG Research Technitian - National Institute of Infectious Diseases
    Naoko Ishii
  • OB - Sloan Kettering Cancer Center, N.Y.
    Melvin Pan
  • OG - Transfer to Medical School
    Arisa Hoashi
  • OG - Laboratory Employment
    Ayaka Hikichi
  • OB Research Student- Pharmaceutical Company Employment
    Tomohiro Arai
  • OG Research Student
    Momoka Ando
  • OG Research Student
    Jinrui Jiang
  • OG Secretary
    Honoka Kurihara
  • OG Secretary - Keio University Medical School
    Ruriko Ikatani


We seek for talented students, technical staff members.
There are several ways to join Osawa Lab.



room image


A new open laboratory was refurbished on the 3rd floor of Building 4 of the Center for Advanced Science and Technology, University of Tokyo.

We provide a relaxed space for study.