Research article in collaboration with Prof. Hideyuki Yanai, Prof. Tadatsugu Taniguchi from RCAST and Prof. Tomoyoshi Soga from Keio university was accepted for publication in PNAS.
PUBLICATION
Tumor cell–derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8+ T cell activation
Proceedings of the National Academy of Sciences (PNAS)
Article：Tumor cell-derived spermidine is an oncometabolite that suppress TCR clustering for intratumoral CD8+ T cell activation
Authors：Sana Hibino, Shotaro Eto, Sho Hangai, Keiko Endo, Sanae Ashitani, Maki Sugaya, Tsuyoshi Osawa, Tomoyoshi Soga, Tadatsugu Taniguchi*, Hideyuki Yanai*
プレスリリース https://www.rcast.u-tokyo.ac.jp/ja/news/release/20230606.html
T細胞応答を抑制するがん代謝物（オンコメタボライト）を発見
―がん免疫療法における新規治療標的としての期待―
