Research Center for Advanced Science and Technology

Osawa Lab. Osawa Lab.


Associate Professor Osawa and Professor Emeritus Kodama in collaboration with Professor Shimamura, Nagoya University and Professor Soga, Keio University published a paper in Cell Reports.




Associate Professor Osawa and Emeritus Professor Kodama, in collaboration with Professor Teppei Shimamura at Nagoya University and Professor Tomoyoshi Soga at Keio University found that accumulation of phosphoethanolamine (PEtn) protected cancer cells under glutamine starvation through the downregulation of PCYT2. Glutamine regulated PE biosynthesis through PCYT2, resulting in protumorigenic metabolite PEtn accumulation. PEtn stimulated the tolerance of cancer cells to starvation, and lowered PCYT2 expression correlates with decreased survival in patients. This research was published in “Cell Reports”.


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