Research Center for Advanced Science and Technology

Osawa Lab. Osawa Lab.

PUBLICATIONS

Osawa T*, Shimamura T*, Saito K, Hasegawa Y, Ishii N, Nishida M, Ando R, Kondo A, Anwar M, Tsuchida R, Hino S, Sakamoto A, Igarashi K, Saitoh K, Kato K, EndoK, Yamano S, Kanki Y, Matsumura Y, Minami T, Tanaka T, Anai M, Wada Y, Wanibuchi H, Hayashi M, Hamada A, Yoshida M, Yachida S, Nakao M, Sakai J, Aburatani H, Shibuya M, Hanada K, Miyano S, Soga T*, Kodama T*. Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2, Cell Reports, 29, 89-103, 2019.

Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S., Takakura N. Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis, Nature Commun, 10:1072, 2019.

Yamamoto R, Osawa T, Sasaki Y, Yamamoto S, Anai M, Izumi K, Matsumura Y, Sakai J, Aburatani H, Mizokami A, Kodama T, Tanaka T. Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth. Oncotarget, 9(12), 10510-10524, 2018.

Kondo A & Osawa T. Establishment of an extracellular acidic pH culture system. JoVE, 129, e56660, 2017

Kondo A, Nonaka A, Shimamura T, Yamamoto S, Yoshida T, Kodama T, Aburatani H and Osawa T. Long non-coding RNA JHDM1D-AS1 promotes tumor growth by regulating angiogenesis in response to nutrient starvation. Molecular and Cellular Biology, 37(18). pii: e00125-17, 2017.

Yamamoto S, Muramatsu M, Azuma E, Ikutani M, Nagai Y, Sagara H, Koo BN, Kita S, O’Donnell E, Osawa T, Takahashi H, Takano K, Dohmoto M, Sugimori M, Usui I, Watanabe Y, Hatakeyama N, Iwamoto T, Komuro I, Takatsu K, Tobe K, Niida S, Matsuda N, Shibuya M, Sasahara M. A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS. Scientific Reports, 7(1) :3855, 2017.

Kanki Y, Nakaki R, Shimamura T, Matsunaga T, Yamamizu K, Katayama S, Suehiro J, Osawa T, Aburatani H, Kodama T, Wada Y, Yamashita J and Minami T, Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation. Nucleic Acids Research, 45:4344-4358, 2017.

Kondo A, Yamamoto S, Nakaki R, Shimamura T, Hamakubo T, Sakai J, Kodama T, Yoshida T, Aburatani H* and Osawa T*. Extracellular Acidic pH Activates the Sterol Regulatory Element-binding Protein 2 to Promote Tumor Progression. Cell Reports, 18, 2228-2242, 2017.

Tsuchida R#, Osawa T#, Wang F, Nishii R, Tsuchida S, Muramatsu M, Das B, Takahashi T, Yuasa Y, Inoue T, Wada Y, Minami T, and Shibuya M: BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors. Oncogene, 33(29):3803-11, 2014.

Méndez-Barbero N, Esteban V, Villahoz S, Escolano A, Urso K, Alfranca A, Rodríguez C, Sánchez SA, Osawa T, Andrés V, Martínez-González J, Minami T, Redondo JM, Campanero MR. A major role for RCAN1 in atherosclerosis. EMBO Mol. Med., 5(12):1901-17, 2013.

Minami T, Jiang S, Schadler K, Suehiro JI, Osawa T, Oike Y, Miura M, Naito M, Kodama T, Ryeom S.The Calcineurin-NFAT-Angiopoietin-2 Signaling Axis in Lung Endothelium Is Critical for the Establishment of Lung Metastases. Cell Reports, pii:S2211-1247(13)00383-5, 2013.

Osawa T* and Shibuya M*: Targeting cancer cells resistant to hypoxia and nutrient starvation to improve anti-angiogeneic therapy. Cell Cycle, 12(16):2519-20, 2013.

Osawa T*, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, and Shibuya M*: Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages. Cancer Research, 73(10):3019-3028, 2013.

Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T, Mogushi K, Tanaka H, Osawa T, Kanki Y, Minami T, Aburatani H, Ohmura M, Kubo A, Suematsu M, Takahashi K, Saya H and Nagano O: Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell. Nature Commun. 3:883, 2012.

Osawa T, Muramatsu M, Tsuchida R, Wang F, Kodama T, Minami T and Shibuya M: Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via downregulating angiogenesis, Proc Natl Acad Sci USA, 108(51):20725-9, 2011.

Wang F, Osawa T, Tsuchida R, Yuasa Y, and Shibuya M: Down-regulation of receptor activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis, Cancer Science, 102(11):2007-13, 2011.

Wang F, Yamauchi M, Muramatsu M, Osawa T, Tsuchida R and Shibuya M: RACK1 regulates VEGF/Flt-1-mediated cell migration via activation of a PI3-K/Akt pathway, Journal of Biological Chemistry, 286(11):9097-106, 2011.

Osawa T, Davies D, and Hartley JA: Mechanism of cell death resulting from DNA interstrand cross-linking in mammalian cells, Cell Death and Disease, 2, e187, 2011.

Osawa T, Tsuchida R, Muramatsu M, Yuasa Y, and Shibuya M: Human glioblastoma cells exposed to long-term hypoxia and nutrient starvation stimulated induction of secondary T cell leukemia in mice, Blood Cancer Journal, 1, e6, 2011.

Muramatsu M, Yamamoto S, Osawa T and Shibuya M: VEGFR-1 signaling promotes mobilization of macrophage-linage cells from bone marrow and stimulates solid tumor growth, Cancer Research, 70(20):8211-21, 2010.

Middleton MR, Knox R, Cattell E, Oppermann U, Midgley R, Ali R, Auton T, Anderson D, Sarker D, Judson I, Osawa T, Spanswick VJ, Davies, S, Hartley JA and Kerr DJ: Quinone oxidoreductase-2-mediated prodrug cancer therapy, Science Translational Medicine, (2): 40ra50, 2010.

Yamamoto S, Muramatsu M, Azuma E, Dohmoto M, Osawa T, Takahashi H, Takano KI, Urakabe S, Niida S, Shibuya M, Matsuda N, Hattori Y: Pericyte Recruitment during the Neurogenesis Period of the Central Nervous System, The Journal of Japanese College of Angiology, 50, 197-201, 2010.

Osawa T, Muramatsu M, Watanabe M and Shibuya M: Hypoxia and low nutrition double stress induces aggressiveness in a murine model of melanoma, Cancer Science, 100(5):844-51, 2009.