PUBLICATIONS
Kato M, Maeda K, Nakahara R, Hirose H, Kondo A, Aki S, Sugaya M, Hibino S, Nishida M, Hasegawa M, Morita H, Ando R, Tsuchida R, Yoshida M, Kodama T, Yanai H, Shimamura T and Osawa T. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of pro-tumor neutrophils. PNAS Nexus, 2(10), pgad 306, 2023.Nakahara R, Aki S, Sugaya M, Hirose H, Kato M, Maeda K, Sakamoto DM, Kojima Y, Nishida M, Ando R, Muramatsu M, Pan M, Tsuchida R, Matsumura Y, Yanai H, Takano H, Yao R, Sando S, Shibuya M, Sakai J, Kodama T, Kidoya H, Shimamura T, and Osawa T. Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth. The EMBO Journal, e114032, 2023.
Hibino S, Eto S, Hangai S, Endo K, Ashitani S, Sugaya M, Osawa T, Soga T, Taniguchi T and Yanai H. Tumor cell–derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8+ T cell activation. Proc Natl Acad Sci USA, 120 (24) e2305245120, 2023.
Aki S, Nakahara R, Maeda K, Osawa T. Cancer metabolism within tumor microenvironments.BBA. May 2023, doi:10.1016/j.bbagen.2023.130330
Kitagawa A, Osawa T, Noda M, Kobayashi Y, Aki S, Nakano Y, Saito T, Shimizu D, Komatsu H, Sugaya M, Takahashi J, Kosai K, Motomura Y, Takao S, Sato K, Hu Q, Fujii A, Wakiyama H, ToBo T, Uchida H, Sugimachi K, Shibata K, Utsunomiya T, Kobayashi S, Ishii H, Hasegawa T, Masuda T, Matsui Y, Niida A, Soga T, Suzuki Y, Miyano S, Aburatani H, Doki Y, Eguchi H, Mori M, Nakayama K, Shimamura T, Shibata T, Mimori K. Convergent Genomic Diversity and Novel BCAA Metabolism in Intrahepatic Cholangiocarcinoma. Br. J. Cancer, 2023 In press.
Nakahara R, Maeda K, Aki S, Osawa T. Metabolic adaptations of cancer in extreme tumor microenvironments.Cancer Science. 114, January 11,2023. doi: 10.1111/cas.15722.
Hirose S, Waku T, Tani M, Masuda H, Endo K, Ashitani S, Aketa I, Ktano H, Nakada S, Wada A, Hatanaka A, Osawa T, Soga T, Kobayashi A. NRF3 activates mTORC1 arginine-dependently for cancer cell viability. iScience. 26, 106045, 2023.
Kaneko Y, Yamatsugu K, Yamashita T, Takahashi K, Tanaka T, Aki S, Tatsumi T, Kawamura T, Miura M, Ishii M, Ohkubo K, Osawa T, Kodama K, Ishikawa S, Tsukagoshi M, Chansler M, Sugiyama A, Kanai M, Katoh H, Pathological complete remission of relapsed tumor by photo-activating antibody–mimetic drug conjugate treatment, Cancer Science, Sep 19, 2022. doi: 10.1111/cas.15565.
Pan M, Zorbas C, Sugaya M, Ishiguro K, Kato M, Nishida M, Zhang H, Candeias MM, Okamoto A, Soga T, Aburatani H, Sakai J, Matsumura Y, Suzuki T, Proud CG, Lafontaine DLJ, Osawa T, Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors. Nature Commun. 13, 3706, 2022. doi:10.1038/s41467-022-31418-w
Nagata N, Nishijima S, Kojima Y, Hisada Y, Imbe K, Miyoshi-Akiyama T, Suda W, Kimura M, Aoki R, Sekine K, Ohsugi M, Miki K, Osawa T, Ueki T, Oka S, Mizokami M, Kartal E, Schmidt TSB, Molina-Montes E, Estudillo L, Malats N, Trebicka J, Kersting S, Langheinrich M, Bork P, Uemura N, Itoi T, and Kawai T. Metagenomic identification of microbial signatures predicting pancreatic cancer from a multinational study. Gastroenterology. 163, 222-238, 2022. doi: 10.1053/j.gastro.2022.03.054.
Murakami K, Sasaki Y, Asahiyama M, Yano W, Takizawa T, Kamiya W, Matsumura Y, Anai M, Osawa T, Fruchart JC, Fruchart-Najib J, Aburatani H, Sakai J, Kodama T, Tanaka T. Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis. Cells. 11(4): 720, 2022. doi: 10.3390/cells11040720.
Yamatsugu K, Katoh H, Yamashita T, Takahashi K, Aki S, Tatsumi T, Kaneko Y, Kawamura T, Miura M, Ishii M, Ohkubo K, Osawa T, Kodama T, Ishikawa S, Kanai M, Sugiyama A. Antibody mimetic drug conjugate manufactured by high-yield Escherichia coli expression and non-covalent binding system. Protein Expr Purif. 192: 106043, 2022. doi:10.1016/j.pep.2021.106043.
Yoneshiro T, Kataoka N, Walejko JM, Ikeda K, Brown Z, Yoneshiro M, Crown SB, Osawa T, Sakai J, McGarrah RW, White PJ,Nakamura K, and Kajimura S. Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever. eLife, 10, e66865, 2021.
Muramatsu M#, Osawa T#, Miyamura Y, Nakagawa S, Tanaka T, Kodama T, Aburatani H, Sakai J, Ryeom S, Minami T. Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background. Journal of Biological Chemistry, 296 : 100697, 2021.
Shirai K, Nagae G, Seki M, Kudo Y, Kamio A, Hayashi A, Okabe A, Ota S, Tsutsumi S, Fujita T, Yamamoto S, Nakaki R, Kanki Y, Osawa T, Midorikawa Y, Tateishi K, Ichinose M, Aburatani H. TET1 upregulation drives cancer cell growth by aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma. Cancer Science, 112(7), 2855-2869, 2021.
Morihiro K, Ishinabe T, Takatsu M, Osumi H, Osawa T, Okamoto A. Fluoxuridine Oligomers Activated under Hypoxic Environment. J. Am. Chem. Soc. 143, 9, 3340–3347, 2021.
Muramatsu M#, Nakagawa S#, Osawa T#, Toyono T, Uemura A, Kidoya H, Takakura N, Usui T, Ryeom S, Minami T. Loss of Down Syndrome Critical Region-1 Mediated-Hypercholesterolemia Accelerates Corneal Opacity Via Pathological Neovessel Formation. Arterioscler Thromb Vasc Biol, 40, 2425-2439, 2020.
Sasaki Y, Asahiyama M, Tanaka T, Yamamoto S, Murakami K, Kamiya W, Matsumura Y, Osawa T, Anai M, Fruchart JC, Aburatani H, Sakai J, Kodama T. Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content. Scientific Reports, 10, 7818, 2020.
Sasaki Y, Raza-Iqbal S, Tanaka T, Murakami K, Anai M, Osawa T, Matsumura Y, Sakai J, Kodama T. Gene Expression Profiles Induced by a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα) Pemafibrate, International Journal of Molecular Sciences, 20, 5682,2019.
Osawa T*, Shimamura T*, Saito K, Hasegawa Y, Ishii N, Nishida M, Ando R, Kondo A, Anwar M, Tsuchida R, Hino S, Sakamoto A, Igarashi K, Saitoh K, Kato K, EndoK, Yamano S, Kanki Y, Matsumura Y, Minami T, Tanaka T, Anai M, Wada Y, Wanibuchi H, Hayashi M, Hamada A, Yoshida M, Yachida S, Nakao M, Sakai J, Aburatani H, Shibuya M, Hanada K, Miyano S, Soga T*, Kodama T*. Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2, Cell Reports, 29, 89-103, 2019.
Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S., Takakura N. Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis, Nature Commun, 10:1072, 2019.
Yamamoto R, Osawa T, Sasaki Y, Yamamoto S, Anai M, Izumi K, Matsumura Y, Sakai J, Aburatani H, Mizokami A, Kodama T, Tanaka T. Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth. Oncotarget, 9(12), 10510-10524, 2018.
Kondo A & Osawa T. Establishment of an extracellular acidic pH culture system. JoVE, 129, e56660, 2017
Kondo A, Nonaka A, Shimamura T, Yamamoto S, Yoshida T, Kodama T, Aburatani H and Osawa T. Long non-coding RNA JHDM1D-AS1 promotes tumor growth by regulating angiogenesis in response to nutrient starvation. Molecular and Cellular Biology, 37(18). pii: e00125-17, 2017.
Yamamoto S, Muramatsu M, Azuma E, Ikutani M, Nagai Y, Sagara H, Koo BN, Kita S, O’Donnell E, Osawa T, Takahashi H, Takano K, Dohmoto M, Sugimori M, Usui I, Watanabe Y, Hatakeyama N, Iwamoto T, Komuro I, Takatsu K, Tobe K, Niida S, Matsuda N, Shibuya M, Sasahara M. A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS. Scientific Reports, 7(1): 3855, 2017.
Kanki Y, Nakaki R, Shimamura T, Matsunaga T, Yamamizu K, Katayama S, Suehiro J, Osawa T, Aburatani H, Kodama T, Wada Y, Yamashita J and Minami T, Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation. Nucleic Acids Research, 45:4344-4358, 2017.
Kondo A, Yamamoto S, Nakaki R, Shimamura T, Hamakubo T, Sakai J, Kodama T, Yoshida T, Aburatani H* and Osawa T*. Extracellular Acidic pH Activates the Sterol Regulatory Element-binding Protein 2 to Promote Tumor Progression. Cell Reports, 18, 2228-2242, 2017.
Tsuchida R#, Osawa T#, Wang F, Nishii R, Tsuchida S, Muramatsu M, Das B, Takahashi T, Yuasa Y, Inoue T, Wada Y, Minami T, and Shibuya M: BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors. Oncogene, 33(29):3803-11, 2014.
Méndez-Barbero N, Esteban V, Villahoz S, Escolano A, Urso K, Alfranca A, Rodríguez C, Sánchez SA, Osawa T, Andrés V, Martínez-González J, Minami T, Redondo JM, Campanero MR. A major role for RCAN1 in atherosclerosis. EMBO Mol. Med., 5(12):1901-17, 2013.
Minami T, Jiang S, Schadler K, Suehiro JI, Osawa T, Oike Y, Miura M, Naito M, Kodama T, Ryeom S.The Calcineurin-NFAT-Angiopoietin-2 Signaling Axis in Lung Endothelium Is Critical for the Establishment of Lung Metastases. Cell Reports, pii:S2211-1247(13)00383-5, 2013.
Osawa T* and Shibuya M*: Targeting cancer cells resistant to hypoxia and nutrient starvation to improve anti-angiogeneic therapy. Cell Cycle, 12(16):2519-20, 2013.
Osawa T*, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, and Shibuya M*: Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages. Cancer Research, 73(10):3019-3028, 2013.
Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T, Mogushi K, Tanaka H, Osawa T, Kanki Y, Minami T, Aburatani H, Ohmura M, Kubo A, Suematsu M, Takahashi K, Saya H and Nagano O: Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell. Nature Commun. 3:883, 2012.
Osawa T, Muramatsu M, Tsuchida R, Wang F, Kodama T, Minami T and Shibuya M: Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via downregulating angiogenesis, Proc Natl Acad Sci USA, 108(51):20725-9, 2011.
Wang F, Osawa T, Tsuchida R, Yuasa Y, and Shibuya M: Down-regulation of receptor activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis, Cancer Science, 102(11):2007-13, 2011.
Wang F, Yamauchi M, Muramatsu M, Osawa T, Tsuchida R and Shibuya M: RACK1 regulates VEGF/Flt-1-mediated cell migration via activation of a PI3-K/Akt pathway, Journal of Biological Chemistry, 286(11):9097-106, 2011.
Osawa T, Davies D, and Hartley JA: Mechanism of cell death resulting from DNA interstrand cross-linking in mammalian cells, Cell Death and Disease, 2, e187, 2011.
Osawa T, Tsuchida R, Muramatsu M, Yuasa Y, and Shibuya M: Human glioblastoma cells exposed to long-term hypoxia and nutrient starvation stimulated induction of secondary T cell leukemia in mice, Blood Cancer Journal, 1, e6, 2011.
Muramatsu M, Yamamoto S, Osawa T and Shibuya M: VEGFR-1 signaling promotes mobilization of macrophage-linage cells from bone marrow and stimulates solid tumor growth, Cancer Research, 70(20):8211-21, 2010.
Middleton MR, Knox R, Cattell E, Oppermann U, Midgley R, Ali R, Auton T, Anderson D, Sarker D, Judson I, Osawa T, Spanswick VJ, Davies, S, Hartley JA and Kerr DJ: Quinone oxidoreductase-2-mediated prodrug cancer therapy, Science Translational Medicine, (2): 40ra50, 2010.
Yamamoto S, Muramatsu M, Azuma E, Dohmoto M, Osawa T, Takahashi H, Takano KI, Urakabe S, Niida S, Shibuya M, Matsuda N, Hattori Y: Pericyte Recruitment during the Neurogenesis Period of the Central Nervous System, The Journal of Japanese College of Angiology, 50, 197-201, 2010.
Osawa T, Muramatsu M, Watanabe M and Shibuya M: Hypoxia and low nutrition double stress induces aggressiveness in a murine model of melanoma, Cancer Science, 100(5):844-51, 2009.
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大澤毅, マルチオミクスによる疾患原因解明への応用, 技術情報協会, 2022.
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大澤毅, 遺伝子制御の新たな主役 栄養シグナル 第1章 新たに見えてきた,栄養・代謝物シグナルによる遺伝子制御メカニズム 1.栄養・代謝物シグナルのメタボローム解析, 実験医学 , 34(15) 2417‐2422, 2016.